GENERAL PHARMACOLOGY
Introduction to the Pharmacology and Toxicology Study. Drug Concept and Pharmacological Action. Origin and classification of drugs. Pharmaceutical preparations. Biotechnological production of drugs.
Pharmacokinetics: Drug administration routes. Drug passage through cell membranes. Absorption, distribution, metabolism and elimination of drugs. Pharmacokinetic parameters.
Pharmacodynamics: Locations and mechanisms of action of drugs. Drug receptors and their classifications. Dose-response relationship. Agonists and antagonists. Factors that change the action of drugs. Habit. Individual variations and drug interactions. Abnormal responses to drug administration: idiosyncrasis, drug allergy.
MOLECULAR PHARMACOLOGY AND NEUROTRASMISSIONS
Drug-receptor binding and signal transduction processes. Principles of autonomic and peripheral nervous system (cholinergic and adrenergic system) and Central Nervous System (glutamatergic neurotransmission, GABA, dopaminergic, serotoninergic, istaminergic, opioid).
SPECIAL PHARMACOLOGY
Peripheral and central nervous system drugs. Medications of the Cardiovascular System, Blood and Kidney. Respiratory Device Drugs. Digestive Plant Drugs. Inflammatory drugs (steroid drugs, non-steroidal drugs). Immune System Drugs. Metabolism Drugs. Hormones and Endocrine System Drugs. Medicines for the treatment of the genitourinary tract.
Antimicrobial chemotherapies Principles of antimicrobial and antineoplastic therapy. Mechanism of action, resistance, spectrum of action, chemoprophylaxis, chemotherapy associations and toxicity: ß-lattamine, macrolides, aminoglycosides, tetracyclines, chloramphenicol, sulfonamides, quinolones. Antiviral and antitumor drugs.
TOXICOLOGY
Development of a new medication and pathway of toxicological studies. Animal experimentation (acute, sub-acute and chronic toxicity). Clinical trial (Phases I, II, III and IV), ethical and scientific limits Mechanisms of toxicity. Antidemic and pharmacological therapy. Characterization of toxicological risk. Teratogenicity. Cancerogenesis and Mutagenesis. Drugs from Doping.
Laboratory testing tools for drug analysis