Università degli Studi di Napoli "Parthenope"

Teaching schedule

Academic year: 
Belonging course: 
Course of Bachelor's Degree Programme on BIOLOGICAL SCIENCES
Disciplinary sector: 
Year of study: 
Dott.ssa MAZZEO Filomena
Second semester
Hours of front activity: 


Course description

The course aims to provide students with the fundamentals of the theoretical and practical of basic and special pharmacology. Starting from the principles of pharmacokinetics and pharmacodynamics, the effects of the major classes of drugs, both at cellular level and on organs and apparatus, and their toxic effects will be illustrated. Pharmacological effects, adverse reactions and interactions between drugs, drugs and food, as well as the main experimental methods used in bio-medical fields in the characterization of molecular and active pharmacologically and/or interesting substances will be investigated toxicity, either in the environmental, food or industrial field.


The student must acquire and assimilate the following knowledge provided by chemistry courses, Biochemistry with Laboratory, General Physiology and Genetics


Introduction to the Pharmacology and Toxicology Study. Drug Concept and Pharmacological Action. Origin and classification of drugs. Pharmaceutical preparations. Biotechnological production of drugs.
Pharmacokinetics: Drug administration routes. Drug passage through cell membranes. Absorption, distribution, metabolism and elimination of drugs. Pharmacokinetic parameters.
Pharmacodynamics: Locations and mechanisms of action of drugs. Drug receptors and their classifications. Dose-response relationship. Agonists and antagonists. Factors that change the action of drugs. Habit. Individual variations and drug interactions. Abnormal responses to drug administration: idiosyncrasis, drug allergy.
Drug-receptor binding and signal transduction processes. Principles of autonomic and peripheral nervous system (cholinergic and adrenergic system) and Central Nervous System (glutamatergic neurotransmission, GABA, dopaminergic, serotoninergic, istaminergic, opioid).
Peripheral and central nervous system drugs. Medications of the Cardiovascular System, Blood and Kidney. Respiratory Device Drugs. Digestive Plant Drugs. Inflammatory drugs (steroid drugs, non-steroidal drugs). Immune System Drugs. Metabolism Drugs. Hormones and Endocrine System Drugs. Medicines for the treatment of the genitourinary tract.
Antimicrobial chemotherapies Principles of antimicrobial and antineoplastic therapy. Mechanism of action, resistance, spectrum of action, chemoprophylaxis, chemotherapy associations and toxicity: ß-lattamine, macrolides, aminoglycosides, tetracyclines, chloramphenicol, sulfonamides, quinolones. Antiviral and antitumor drugs.
Development of a new medication and pathway of toxicological studies. Animal experimentation (acute, sub-acute and chronic toxicity). Clinical trial (Phases I, II, III and IV), ethical and scientific limits Mechanisms of toxicity. Antidemic and pharmacological therapy. Characterization of toxicological risk. Teratogenicity. Cancerogenesis and Mutagenesis. Drugs from Doping.
Laboratory testing tools for drug analysis

Teaching Methods



Learning assessment

The objective of the exam is to check the level of achievement of the training objectives previously indicated. The verific examination is oral

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