PHARMACOLOGY AND TOXICOLOGY
The course aims to provide students with the fundamentals of the theoretical and practical of basic and special pharmacology. Starting from the principles of pharmacokinetics and pharmacodynamics, the effects of the major classes of drugs, both at cellular level and on organs and apparatus, and their toxic effects will be illustrated. Pharmacological effects, adverse reactions and interactions between drugs, drugs and food, as well as the main experimental methods used in bio-medical fields in the characterization of molecular and active pharmacologically and/or interesting substances will be investigated toxicity, either in the environmental, food or industrial field.
The student must acquire and assimilate the following knowledge provided by chemistry courses, Biochemistry with Laboratory, General Physiology and Genetics
Introduction to the Pharmacology and Toxicology Study. Drug Concept and Pharmacological Action. Origin and classification of drugs. Pharmaceutical preparations. Biotechnological production of drugs.
Pharmacokinetics: Drug administration routes. Drug passage through cell membranes. Absorption, distribution, metabolism and elimination of drugs. Pharmacokinetic parameters.
Pharmacodynamics: Locations and mechanisms of action of drugs. Drug receptors and their classifications. Dose-response relationship. Agonists and antagonists. Factors that change the action of drugs. Habit. Individual variations and drug interactions. Abnormal responses to drug administration: idiosyncrasis, drug allergy.
MOLECULAR PHARMACOLOGY AND NEUROTRASMISSIONS
Drug-receptor binding and signal transduction processes. Principles of autonomic and peripheral nervous system (cholinergic and adrenergic system) and Central Nervous System (glutamatergic neurotransmission, GABA, dopaminergic, serotoninergic, istaminergic, opioid).
Peripheral and central nervous system drugs. Medications of the Cardiovascular System, Blood and Kidney. Respiratory Device Drugs. Digestive Plant Drugs. Inflammatory drugs (steroid drugs, non-steroidal drugs). Immune System Drugs. Metabolism Drugs. Hormones and Endocrine System Drugs. Medicines for the treatment of the genitourinary tract.
Antimicrobial chemotherapies Principles of antimicrobial and antineoplastic therapy. Mechanism of action, resistance, spectrum of action, chemoprophylaxis, chemotherapy associations and toxicity: ß-lattamine, macrolides, aminoglycosides, tetracyclines, chloramphenicol, sulfonamides, quinolones. Antiviral and antitumor drugs.
Development of a new medication and pathway of toxicological studies. Animal experimentation (acute, sub-acute and chronic toxicity). Clinical trial (Phases I, II, III and IV), ethical and scientific limits Mechanisms of toxicity. Antidemic and pharmacological therapy. Characterization of toxicological risk. Teratogenicity. Cancerogenesis and Mutagenesis. Drugs from Doping.
Laboratory testing tools for drug analysis
- General pharmacology: Pharmacokinetics and Pharmacodinamic
- MOLECULAR PHARMACOLOGY AND NEUROTRASMISSIONS
- SPECIAL PHARMACOLOGY
The objective of the exam is to check the level of achievement of the training objectives previously indicated. The verific examination is oral
- Casa Editrice Ambrosiana. Distribuzione esclusiva Zanichelli 2006
- Le basi della farmacologia Autori: Clark - Finkel - Rey - Whalen Editore: Zanichelli 2013
- Principi di farmacologia Classificazione. Interazioni. Indicazioni cliniche. Autori: Henry Hitner, Barbara Nagle Edizione italiana a cura di A. Sala 2014
- Farmacologia Integrata. Autori: C. P. Page, M. J. Curtis, M. C. Sutter, M. J. A. Walker, B. B. Hoffman. Edizioni Ambrosiana
- Farmacologia. Autori: Rang H.p., Dale M.m. , Ritter J.m., Flower R.j., Henderson G. Editore Masson-Edra
- Farmacologia : principi di base e applicazioni terapeutiche F. Rossi, V. Cuomo , C. Ricciardi,(Eds) .Edizioni Minerva Medica, Torino, 2011.
- Farmacologia generale e clinica di Bertram G. Katzung, Anthony J. Trevor Editore:Piccin-Nuova Libraria