The aim of the course is to provide the student with the knowledge of the pathogenetic, molecular and cellular mechanisms underlying some of the frequently recognized human diseases.
The reactions to the different causes of the disease will be treated, the morphological alterations that these cause in the cells and in the tissues with the functional consequences for the organism. The role of physical activity on the main chronic diseases will be analyzed.
Prerequisites non-binding are basic concepts of biology, biochemistry, anatomy and physiology.
Cellular damage: Causes of cellular damage. Mechanisms of cell damage. Cell adaptation. Reversible and irreversible damage. Necrosis. Apoptosis.
Acute inflammation: Definition and causes of acute inflammation. Stages of acute inflammation. The cells of acute inflammation. The chemical mediators of inflammation. Types of acute inflammation and of exudate.
Chronic inflammation: Classification, causes and types of chronic inflammation. Cells of chronic inflammation. Typical lesions of chronic inflammation. Granulomas.
Systemic phenomena associated with inflammation.
Renewal, regeneration and tissue repair.
Neoplasia: natural history, benign and malignant tumors, diagnosis, classification, staging, oncogenes, tumor suppressors, cell cycle, inheritance and tumors, angiogenesis, invasion and metastasis, chemical and physical carcinogenesis. Neoplastic stem cells. Immunity and tumors.
Adapted physical activity and cancer: Role of physical activity in primary, secondary and tertiary prevention of tumors, mechanisms of action of physical activity in oncology, physical activity and more frequent human tumors, limitations of physical activity in oncology.
Pathology of lymphoid and hematopoietic tissues: Pathophysiology of the haematopoietic system. Classification, genetics, etiology and pathogenesis of anemia. Anemias in the sportsman. Myeloproliferative syndromes. Acute and chronic leukemias. Lymphomas. Multiple myeloma.
Pathophysiology of haemostasis. Plateletopathy and platelet diseases.
Diabetes mellitus: classification, glucose homeostasis, pathogenesis of type 1 and 2 diabetes, monogenic forms of diabetes, gestational diabetes, pathogenesis of diabetes complications.
Renewal, regeneration and tissue repair. Neoplasia.
Physical activity and cancer.
Pathology of lymphoid and hematopoietic tissues.
Pontieri. Elementi di Patologia generale & Fisiopatologia generale. IV Edizione. Piccin.
Robbins. Fondamenti di Patologia e di Fisiopatologia. Edra
Buono. Attività fisica per la salute. Seconda Edizione. Idelson Gnocchi.
Any text updated according to the program. Further updated scientific articles will be provided by the teacher.
Final exam: An oral exam in which the knowledge of the different topics covered during the course will be assessed, the ability to synthesis, the clarity and correctness of the exposure and the ability to link and integrate the contents.