BIOCHEMISTRY AND BIOENERGETICS OF EXERCISE
Acquisition of knowledge about the metabolism of the main energy substrates such as carbohydrates, fatty acids and aminoacids. Energy balance of the anaerobic and aerobic mechanisms in skeletal muscle of human.
Basic knowledge of Human Biochemistry.
Biomolecules: outline of structure and functional properties.Flow of energy in living organisms: principles of bioenergetic and thermodynamic relations.ATP and energy-rich compounds. Structure of skeletal muscle tissue. Energy substrates of skeletal muscle.General concepts of metabolism: anabolic, catabolic and amphibolic pathways.Skeletal muscle metabolism: classification of muscle fibers and biochemistry of contraction. Skeletal muscle bioenergetics: energy sources and mechanisms of ATP synthesis.Anaerobic-alactacid mechanisms: phosphocreatine and myokinase.Anaerobic-lactacid mechanisms: glycolysis and fate of pyruvate. Lactic fermentation. Monocarboxylate transporters (MCT). Utilization of the lactate. Cori cycle. Methods of measurement of blood lactate. Oxygen debt.Glycogen: structure, function and metabolism. Role of muscle glycogen in function of physical activity and energy balance.Aerobic mechanisms: the pyruvate dehydrogenase complex and its regulation. Krebs cycle and energy balance. Triglycerides and adipose tissue. Mobilization and delivery of fatty acids. Activation of fatty acids and the carnitine mitochondrial transport system. Beta-oxidation of fatty acids and energy balance. Outline of amino acid oxidation: transaminases and urea production. Mitochondria, membrane transporters and shuttle systems.Oxidative phosphorylation: reactions, electron transport chain and ATP synthesis. Mechanism of ATP synthesis and ATP synthase complex (FOF1). Energy balance. Uncoupling proteins and agents.Reactive oxygen species (ROS) and health. Physical activity and ROS production.
Reading and commentary of scientific articles on applied aspects of Bioenergetics in Sport Sciences.
The Biochemistry and Bioenergetics of the Human Physical Exercise course illustrates the main energy substrates used by skeletal muscle in human in relation to the different types of physical activity. The mechanisms of anaerobic and oxidative energy production and their energy balance are deepened.
The course includes classroom lectures. Students can take advantage of an electronic version of the didactic material used in frontal lessons.Critical reading of the recent bibliography on the topics discussed in the classroom lessons.
NELSON D.L., COX M.M., “Lehninger Principles of Biochemistry”, Macmillan Education Eds.MOUGIOS V., "Exercise Biochemistry", Human Kinetics Eds.MORAN L.A., HORTON R.A., SCRIMGEOUR G., PERRY M.D., “Principles of Biochemistry, 5/E”, Pearson Education Eds.
Progress tests during the course by multiple-choice and open-ended questions, on the topics addressed up to the time of the test.The final test consists of an oral exam on all the contents of the course.
Recent scientific articles will be made available by the teacher.