Università degli Studi di Napoli "Parthenope"

Teaching schedule

Academic year: 
2019/2020
Belonging course: 
Course of Master's Degree Programme on MOVEMENT SCIENCES FOR PREVENTION AND WELLBEING
Disciplinary sector: 
EXPERIMENTAL BIOLOGY (BIO/13)
Language: 
Italian
Credits: 
9
Year of study: 
2
Teachers: 
Cycle: 
Second semester
Hours of front activity: 
72

Language

Italian

Course description

Objectives.
The course aims at providing students with basic knowledge in
1) Cell-to cell communication
2) Principles of Development and Differentiation
3) Molecular mechanisms of cell biogenesis, turnover, homeostasis, aging and death
4) The flow of Genetic information and the regulation of gene expression
5) Epigenetics and consequences on health status
6) Basic Genetics and the applications of biotechnologies to improve heath

Expected learning outcomes:
o Knowledge and understanding
The student has to learn:1) basic biological processes (i.e. cell to cell communications, development, differentiation, tissue turnover and homeostasis, cell aging and death); 2) the importance of DNA and the impact of the environment -which include exercises- on gene expression in order to maintain health status; 3) basic genetics and the possible therapeutic use of biotechnology.

o Applying knowledge and understanding
The student’ll apply knowledge to:
• identify and compare the different cell to cell communications
• understand the molecular mechanisms of cell biogenesis, turnover, homeostasis, aging and death
• understand the relationship between DNA function and environment in order to promote suitable life stiles
• understand the basic mechanism for the transmission of hereditary diseases and promote the correct use of biotechnology to maintain and preserve health status and wellness.

o Making judgements
The student has to gain the e skill to select the appropriate scientific sources in order to make correct data integration and interpretation.
o Communication
The student has to explain the acquired knowledge using a proper scientific language, thus demonstrating a full comprehension of the course topics.
o Lifelong learning skills
The student has to develop the appropriate learning method in order to easily improve and upgrade his skills/knowledge

Prerequisites

none

Syllabus

Cell to cell communications (2ects): Plasma membrane, extracellular matrix; Cell-cell interactions; Cell junctions; Autocrine, paracrine, endocrine, neural and neuroendocrine communication; molecular signals; cell surface receptors (Signal transduction and second messengers); Nuclear receptors and action of steroid hormones
Cell Cycle, Mitosis, Meiosis, Development, Differentiation, Aging and Cell Death (2ects): Mitotic Cell Cycle (2ects): progression and checkpoints; growth factors, mitogens and survival factors; Meoisis, gametogenesis and fertilization; genomic equivalence; cellular determination and master genes; tissue turnover and homeostasis; Stem cells (basics, classification and applications), adult stem cells in tissue turnover, homeostasis and regeneration; The biology of Aging (cell damage in DNA, protein, cell membrane, organelles and cytoskeleton, the involvement of mitochondrion and mtDNA); primary and secondary defences; Cell death (Apoptosis necrosis and autophagy)
The flow of Genetic information and the regulation of gene expression (1ects); The flow of Genetic information; Chromatin structure; The regulation of gene expression; Non coding RNA
Epigenetics (1ects): The interplay between genes and environment; Definition and mechanisms; Epigenetic reprogramming in mammalian development; Life style and epigenetics
Genetics (1.5ects): Pedigree Analysis and Monofactorial inheritance (Autosomal dominant/recessive inheritance, X- and Y-linked inheritance); Sex determination; Allele interactions, multiple alleles, and ABO system; Genetic disorder of the skeletal muscle; Extranuclear inheritance (Mitochondrial genome, characteristics and inheritance, mutations of mitochondrial genome and aging, main mitochondrial myopathies); Genetics and sport, Gene polymorphisms and sport performance; DNA Mutations (Changes in chromosome number, chromosome structure and Gene Mutations, causes and consequences); DNA repair mechanisms
Biotechnology (1.5ects): Applications of DNA recombination technology; Gene therapy and Cell therapy; Gene doping; Bioetics

The aim of this course is the fundamental learning of: cell-to-cell communications; cellular and molecular mechanisms leading to development, differentiation, tissue renewal and cell turnover, cell aging and death; the impact of DNA functionality on health status and the epigenetics; the genetic inheritance in human and the applications of biotechnologies to improve heath

Teaching Methods

Face to face lessons, exercises, seminars and discussion of scientific articles

Textbooks

Pierantoni, Cobellis, Meccariello, Chianese: Fondamenti di biologia e genetica Edises

G. De Leo, S. Fasano, E. Ginelli Biologia e Genetica ediSES

Fantoni - Bozzaro - Del Sal – Ferrari Biologia cellulare Piccin editore

Learning assessment

Oral examination and analysis of a recent scientific article using methodological tools discussed in class or explained in the text books.

The student has to explain the acquired knowledge using a proper scientific language, thus demonstrating a full comprehension of the course topics.

More information

Lectures are in Italian. The professor is fluent in English and is available to interact with students in English, also during the examination.